At least two isoforms of FAM193B are known to exist; DPABH-02108 will detect both isoforms.FAM193B, also known as IRIZIO, was initially identified as a protein that is upregulated in alveolar rhabdomyosarcoma (ARMS), a type of fast-growing tumor characterized by chromosomal translocations fusing the PAX3 or PAX7 gene with that of FOXO1. It has been suggested that, in addition to the PAX3-FOXO1 gene fusion, disruption of the Rb and p53 pathways is required for full ARMS tumorigenesis. In PAX3-FOXO1-expressing primary mouse fibroblasts that possessed a defective p53 pathway, FAM193B expression enabled the tumorigenic transformation, suggesting that FAM193B may contribute to rhabdomyosarcomagenesis in humans.Store at 4°C or -20°C long term. Avoid repeated freeze / thaw cycles. Store undiluted. *   http://www.creative-diagnostics.com/Anti-FAM193B-PAb-199885-147.htm